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Article

MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral tolerance.

Molecular cell - 11 Apr 2013

Zmajkovicova Katarina, Jesenberger Veronika, Catalanotti Federica, Baumgartner Christian, Reyes Gloria, Baccarini Manuela

Abstract excerpt

The Raf/MEK/ERK and PI3K/Akt pathways are prominent effectors of oncogenic Ras. These pathways negatively regulate each other, but the mechanism involved is incompletely understood. We now identify MEK1 as an essential regulator of lipid/protein phosphatase PTEN, through which it controls phosphatidylinositol-3-phosphate accumulation and AKT signaling. MEK1 ablation stabilizes AKT activation and, in vivo, causes...

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Source

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Identifiers

PMID: 23453810
DOI: 10.1016/j.molcel.2013.01.037
PMCID: PMC3625979

Genes

PTEN
MAGI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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