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Article

Thermostabilization of Bacillus circulans xylanase: computational optimization of unstable residues based on thermal fluctuation analysis.

Journal of biotechnology - 10 Jan 2011

Joo Jeong Chan, Pack Seung Pil, Kim Yong Hwan, Yoo Young Je

Abstract excerpt

Low thermostability often hampers the applications of xylanases in industrial processes operated at high temperature, such as degradation of biomass or pulp bleaching. Thermostability of enzymes can be improved by the optimization of unstable residues via protein engineering. In this study, computational modeling instead of random mutagenesis was used to optimize unstable residues of Bacillus circulans xylanase...

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Source

Identifiers

PMID: 20959126
DOI: 10.1016/j.jbiotec.2010.10.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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