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Article

Loss of Cdc20 causes a securin-dependent metaphase arrest in two-cell mouse embryos.

Molecular and cellular biology - 1 May 2007

Li Min, York J Philippe, Zhang Pumin

Abstract excerpt

The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase mediating targeted proteolysis through ubiquitination of protein substrates to control the progression of mitosis. The APC/C recognizes its substrates through two adapter proteins, Cdc20 and Cdh1, which contain similar C-terminal domains composed of seven WD-40 repeats believed to be involved in interacting with their substrates. During...

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Source

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Identifiers

PMID: 17325031
DOI: 10.1128/MCB.02088-06
PMCID: PMC1899968

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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