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Article

Endothelial histamine H1 receptor signaling reduces blood-brain barrier permeability and susceptibility to autoimmune encephalomyelitis.

Proceedings of the National Academy of Sciences of the United States of America - 2 Nov 2010

Lu Changming, Diehl Sean A, Noubade Rajkumar, Ledoux Jonathan, Nelson Mark T, Spach Karen, Zachary James F, Blankenhorn Elizabeth P, Teuscher Cory

Abstract excerpt

Disruption of the blood-brain barrier (BBB) underlies the development of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis. Environmental factors, such as Bordetella pertussis, are thought to sensitize central endothelium to biogenic amines like histamine, thereby leading to increased BBB permeability. B. pertussis-induced histamine sensitization (Bphs) is a monogenic intermediate phenotype...

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Source

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Identifiers

PMID: 20956310
DOI: 10.1073/pnas.1008816107
PMCID: PMC2973887

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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