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Article

Identification of Bphs, an autoimmune disease locus, as histamine receptor H1.

Science (New York, N.Y.) - 26 Jul 2002

Ma Runlin Z, Gao Jianfeng, Meeker Nathan D, Fillmore Parley D, Tung Kenneth S K, Watanabe Takeshi, Zachary James F, Offner Halina, Blankenhorn Elizabeth P, Teuscher Cory

Abstract excerpt

Bphs controls Bordetella pertussis toxin (PTX)-induced vasoactive amine sensitization elicited by histamine (VAASH) and has an established role in autoimmunity. We report that congenic mapping links Bphs to the histamine H1 receptor gene (Hrh1/H1R) and that H1R differs at three amino acid residues in VAASH-susceptible and -resistant mice. Hrh1-/- mice are protected from VAASH, which can be restored by genetic...

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Share to Encephalomyelitis, Autoimmune, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12142541
DOI: 10.1126/science.1072810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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