Article
Temporal kinetics and cellular phenotype of TNF p55/p75 receptors in experimental allergic encephalomyelitis.
Journal of neuroimmunology - 1 Mar 1999
Kahn M A, Dopp J M, Liva S, MacKenzie-Graham A J, Chang R, Huang A, Nazarian R, Dell'Albani P, Condorelli D, Voskuhl R R, de Vellis J
Abstract excerpt
TNF-alpha and LT-alpha are thought to be involved in the immunopathology of CNS demyelinating diseases. Both cytokines induce cellular effects through 55-kDa type-1 receptors (R1) and 75-kDa type-2 receptors (R2). To date, no study has specifically identified the various cell populations that express TNF receptors (TNFR) in the inflammatory and demyelinating mouse model, EAE. Phenotyping the TNFR positive cells...
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