Article
Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1993
Sudweeks J D, Todd J A, Blankenhorn E P, Wardell B B, Woodward S R, Meeker N D, Estes S S, Teuscher C
Abstract excerpt
Pertussis toxin (PTX) is the primary component responsible for eliciting the majority of biological activities associated with Bordetella pertussis, including the induction of several tissue-adjuvant models of organ-specific autoimmune disease. PTX, when administered in vivo, enhances vascular permeability, which is made manifest by a concomitant increase in sensitivity to a variety of agents and treatments...
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