Article
Revisiting the recurrence risk of nonsyndromic cleft lip with or without cleft palate.
American journal of medical genetics. Part A - 1 Nov 2010
Klotz Cherise M, Wang Xiaojing, Desensi Rebecca S, Grubs Robin E, Costello Bernard J, Marazita Mary L
Abstract excerpt
Sub-epithelial defects (i.e., discontinuities) of the superior orbicularis oris (OO) muscle appear to be a part of the phenotypic spectrum of cleft lip with or without cleft palate (CL ± P). Analysis of the OO phenotype as a clinical tool is hypothesized to improve familial recurrence risk estimates of CL ± P. Study subjects (n = 3,912) were drawn from 835 families. Occurrences of CL ± P were compared in families...
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