Article
Recurrence risks for neural tube defects in siblings of patients with lipomyelomeningocele.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2005
Sebold Courtney Drake, Melvin Elizabeth C, Siegel Debbie, Mehltretter Lorraine, Enterline David S, Nye Jeffrey S, Kessler John, Bassuk Alexander, Speer Marcy C, George Timothy M
Abstract excerpt
PURPOSE: Neural tube defects (NTDs) are a group of widely varying congenital malformations resulting from incomplete or improper fusion of the neural tube during embryonic development. NTDs are traditionally classified by the presence or absence of a layer of skin covering the spinal defect. Although a genetic component has been well established in the etiology of open NTDs, studies examining the genetics of...
Topics
- Case-Control Studies
- Female
- Genetic Predisposition to Disease
- Genetic Testing
- Humans
- Male
- Meningomyelocele
- Neural Tube Defects
- Pedigree
- Risk Factors
- Siblings