Article
Ultrasonographic detection of orbicularis oris defects in first degree relatives of isolated cleft lip patients.
American journal of medical genetics - 17 Jan 2000
Martin R A, Hunter V, Neufeld-Kaiser W, Flodman P, Spence M A, Furnas D, Martin K A
Abstract excerpt
The phenotypic variability of non-syndromic cleft lip (CL) is broad. We demonstrate that the prevalence of orbicularis oris (OO) muscle anomalies, detectable only by ultrasound, is higher in first-degree relatives of individuals with overt CL than in the general population. These findings suggest that occult OO defects may be part of the spectrum of the CL phenotype, that offspring of individuals with such...
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