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Targeted, Deep Sequencing Reveals Full Methylation Profiles of Multiple HPV Types and Potential Biomarkers for Cervical Cancer Progression

9 Jan 2017

Abstract excerpt

Abstract Background: Invasive cervical cancer (ICC) and its premalignant phase (cervical intraepithelial neoplasia; CIN1-3) are distinguished by gynecologic and pathologic examination, yet no current methodologies can predict precancerous lesions that are destined to progress to ICC. Thus, development of reliable assays to assess patient prognosis is much needed. Methods: Human papillomavirus (HPV) DNA...

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PMID: 28069683
DOI: 10.1158/1055-9965.epi-16-0368

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