Article
Differential methylation of E2 binding sites in episomal and integrated HPV 16 genomes in preinvasive and invasive cervical lesions.
International journal of cancer - 1 May 2013
Chaiwongkot Arkom, Vinokurova Svetlana, Pientong Chamsai, Ekalaksananan Tipaya, Kongyingyoes Bunkerd, Kleebkaow Pilaiwan, Chumworathayi Bandit, Patarapadungkit Natcha, Reuschenbach Miriam, von Knebel Doeberitz Magnus
Abstract excerpt
Enhanced expression of the HPV 16 E6-E7 oncogenes may trigger neoplastic transformation of the squamous epithelial cells at the uterine cervix. The HPV E2 protein is a key transcriptional regulator of the E6-E7 genes. It binds to four E2 binding sites (E2BSs 1-4) in the viral upstream regulatory region (URR). Modification of E2 functions, for example, by methylation of E2BSs is hypothesized to trigger enhanced...
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