Methylation of HPV18, HPV31, and HPV45 genomes and cervical intraepithelial neoplasia grade 3.

doi:10.1093/jnci/djs425

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Article

Methylation of HPV18, HPV31, and HPV45 genomes and cervical intraepithelial neoplasia grade 3.

Journal of the National Cancer Institute - 21 Nov 2012

Wentzensen Nicolas, Sun Chang, Ghosh Arpita, Kinney Walter, Mirabello Lisa, Wacholder Sholom, Shaber Ruth, LaMere Brandon, Clarke Megan, Lorincz Attila T, Castle Philip E, Schiffman Mark, Burk Robert D

Abstract excerpt

BACKGROUND: Persistent infections with carcinogenic human papillomavirus (HPV) types are the necessary cause of cervical cancer. We recently demonstrated that the HPV16 genome is strongly methylated in cervical precancer compared with transient infections. However, the extent of methylation in other HPV types and its role in progression to cancer is poorly understood. METHODS: We analyzed whole-genome methylation...

Topics

Adult
Alphapapillomavirus
Case-Control Studies
DNA Methylation
DNA, Viral
Female
Genome, Viral
Genotype
Human papillomavirus 18
Human papillomavirus 31

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Logistic Models

Middle Aged

Neoplasm Grading

Papillomavirus Infections

Precancerous Conditions

Sample Size

Uterine Cervical Dysplasia

Source

Open in PubMed Open full text

Identifiers

PMID: 23093560
DOI: 10.1093/jnci/djs425
PMCID: PMC3571257

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