Article
Numerical, morphological and phenotypic changes in Langerhans cells in the course of murine graft-versus-host disease.
The British journal of dermatology - 1 Dec 2001
Asagoe K, Takahashi K, Yoshino T, Kondo E, Tanaka R, Arata J, Akagi T
Abstract excerpt
BACKGROUND: In the course of graft-versus-host disease (GVHD) or diseases that histologically mimic GVHD (e.g. toxic epidermal necrolysis, Stevens-Johnson syndrome), it is known that epidermal Langerhans cells (LCs) are depleted from the epidermis. However, the mechanism and significance of LC depletion is not well known. OBJECTIVES: To investigate the numerical, morphological and phenotypic changes in LCs and...
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