Teichoic acids are temporal and spatial regulators of peptidoglycan cross-linking in Staphylococcus aureus.

doi:10.1073/pnas.1004304107

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Article

Teichoic acids are temporal and spatial regulators of peptidoglycan cross-linking in Staphylococcus aureus.

Proceedings of the National Academy of Sciences of the United States of America - 2 Nov 2010

Atilano Magda L, Pereira Pedro M, Yates James, Reed Patricia, Veiga Helena, Pinho Mariana G, Filipe Sérgio R

Abstract excerpt

The cell wall of Staphylococcus aureus is characterized by an extremely high degree of cross-linking within its peptidoglycan (PGN). Penicillin-binding protein 4 (PBP4) is required for the synthesis of this highly cross-linked peptidoglycan. We found that wall teichoic acids, glycopolymers attached to the peptidoglycan and important for virulence in Gram-positive bacteria, act as temporal and spatial regulators...

Topics

Cell Membrane
Mutation
Penicillin-Binding Proteins
Peptidoglycan
Staphylococcus aureus
Teichoic Acids

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Identifiers

PMID: 20944066
DOI: 10.1073/pnas.1004304107
PMCID: PMC2973906

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