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Article

Determinants of murein hydrolase targeting to cross-wall of Staphylococcus aureus peptidoglycan.

The Journal of biological chemistry - 23 Mar 2012

Frankel Matthew B, Schneewind Olaf

Abstract excerpt

Cells of eukaryotic or prokaryotic origin express proteins with LysM domains that associate with the cell wall envelope of bacteria. The molecular properties that enable LysM domains to interact with microbial cell walls are not yet established. Staphylococcus aureus, a spherical microbe, secretes two murein hydrolases with LysM domains, Sle1 and LytN. We show here that the LysM domains of Sle1 and LytN direct...

Topics

Bacterial Proteins
Cell Wall
Mutation
N-Acetylmuramoyl-L-alanine Amidase
Peptidoglycan
Protein Structure, Tertiary
Staphylococcus aureus

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 22303016
DOI: 10.1074/jbc.M111.336404
PMCID: PMC3323028

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