The genetics and neuropathology of Parkinson's disease.

doi:10.1007/s00401-012-1013-5

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Article

The genetics and neuropathology of Parkinson's disease.

Acta neuropathologica - 1 Sept 2012

Houlden Henry, Singleton Andrew B

Abstract excerpt

There has been tremendous progress toward understanding the genetic basis of Parkinson's disease and related movement disorders. We summarize the genetic, clinical and pathological findings of autosomal dominant disease linked to mutations in SNCA, LRRK2, ATXN2, ATXN3, MAPT, GCH1, DCTN1 and VPS35. We then discuss the identification of mutations in PARK2, PARK7, PINK1, ATP13A2, FBXO7, PANK2 and PLA2G6 genes. In...