Article
Methionine sulfoxide reductase A down-regulation in human breast cancer cells results in a more aggressive phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 26 Oct 2010
De Luca Antonella, Sanna Fabio, Sallese Michele, Ruggiero Carmen, Grossi Mauro, Sacchetta Paolo, Rossi Cosmo, De Laurenzi Vincenzo, Di Ilio Carmine, Favaloro Bartolo
Abstract excerpt
Breast cancer is one of the most frequent of human malignancies, and it is therefore fundamental to identify the underlying molecular mechanisms leading to cancer transformation. Among other causative agents in the development of breast cancers, an important role for reactive oxygen species (ROS) has emerged. However, most studies on the role of ROS in cancer have not reached specific conclusions, and many issues...
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