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Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis

21 Oct 2024

Abstract excerpt

The limited availability of therapeutic options for patients with triple-negative breast cancer (TNBC) contributes to the high rate of metastatic recurrence and poor prognosis. Ferroptosis is a type of cell death caused by iron-dependent lipid peroxidation and counteracted by the antioxidant activity of the selenoprotein GPX4. Here, we show that TNBC cells secrete an anti-ferroptotic factor in the extracellular...

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PMID: 39433871
DOI: 10.1038/s44321-024-00142-x

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