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Article

Severe impairment in early host defense against Listeria monocytogenes in mice deficient in acid sphingomyelinase.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2003

Utermöhlen Olaf, Karow Ulrike, Löhler Jürgen, Krönke Martin

Abstract excerpt

The phagolysosomal compartment is crucial for the defense against infection with intracellular pathogens. Within this compartment, the TNF- and IFN-gamma-responsive acid sphingomyelinase (ASMase) generates the signaling molecule ceramide, resulting in the activation of proteases like cathepsin D. To investigate the possible role of ASMase as a mediator of the antibacterial effects of TNF and IFN-gamma,...

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Source

Identifiers

PMID: 12594290
DOI: 10.4049/jimmunol.170.5.2621

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Severe impairment in early host defense against Listeria monocytogenes in mice deficient in acid sphingomyelinase.PMID 12594290Read ↗

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