Application of knockout mice to the experimental analysis of infections with bacteria and protozoa.

doi:10.1016/0966-842x(94)90628-9

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Article

Application of knockout mice to the experimental analysis of infections with bacteria and protozoa.

Trends in microbiology - 1 Jul 1994

Kaufmann S H, Ladel C H

Abstract excerpt

Knockout mice with distinct gene deletions are valuable tools for in vivo analyses of the immune response against infectious agents. Studies of bacterial and protozoal infections have shown that antimicrobial immunity is generally defective in knockout mice. At one extreme, deletion of just one g...

Topics

Animals
Bacterial Infections
Cytokines
Histocompatibility Antigens
Immunity, Innate
Mice
Mice, Knockout
Mutation
Protozoan Infections
T-Lymphocytes

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