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Deep Sequencing of Hepatitis B Virus Reveals Clinically Relevant Low-Frequency Variants Among People Living with HIV in Botswana.

Viruses - 17 Aug 2026

Sethibe Tsholofelo, Choga Wonderful Tatenda, Gaongalelwe Florence G, Phinius Bonolo B, Mpebe Gorata G A, Baruti Kabo, Tsayang Chanana Dorcus, Mbae Goabaone, Phakedi Basetsana Katlo S, Motshosi Patience, Mpofu-Dobo Linda, Jongman Mosimanegape, Moyo Sikhulile, Anderson Motswedi, Gaseitsiwe Simani

Abstract excerpt

(1) Background: The Hepatitis B virus (HBV) is characterized by extensive genetic diversity, including low-frequency variants that contribute to disease progression. We aimed to characterize low-frequency variants and evaluate their potential clinical impact. (2) Methods: We utilized 104 HBV near-full-length sequences generated using next-generation sequencing (NGS) from people living with HIV (PLHIV). We used an...

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Identifiers

PMID: 42655721
DOI: 10.3390/v18080904
PMCID: PMC13517587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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