Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p27(Kip1) deficiency promotes prostate carcinogenesis but does not affect the efficacy of retinoids in suppressing the neoplastic process.

BMC cancer - 8 Oct 2010

Taylor Winna, Mathias Amanda, Ali Arshia, Ke Hengning, Stoynev Nikolay, Shilkaitis Anne, Green Albert, Kiyokawa Hiroaki, Christov Konstantin

Abstract excerpt

BACKGROUND: p27 is a cell cycle suppressor gene, whose protein is a negative regulator of cyclin/cdk complexes. p27 is also a potential target of retinoids in cancer prevention studies. In benign prostate hyperplasia (BPH), and in most carcinomas, p27(Kip1) is down-regulated, suggesting its potential resistance to retinoids. To test this hypothesis, we examined the efficacy of 9-cis retinoic acid (9cRA) to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Cell Cycle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Cyclin-Dependent Kinase Inhibitor p27

Share to Gene Expression Regulation, Neoplastic

Share to Prostatic Neoplasms

Share to Retinoids

Share to Tretinoin

Source

Open in PubMed Open full text

Identifiers

PMID: 20932324
DOI: 10.1186/1471-2407-10-541
PMCID: PMC2958951

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p27(Kip1) deficiency promotes prostate carcinogenesis but does not affect the efficacy of retinoids in suppressing the neoplastic process.PMID 20932324Read ↗

A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression.Semantic proximity Read ↗

Conditional Deletion of <b> <i>Rb</i> </b> Causes Early Stage Prostate CancerSemantic proximity Read ↗

A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis.Semantic proximity Read ↗

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors.Semantic proximity Read ↗

Combined loss of p21(waf1/cip1) and p27(kip1) enhances tumorigenesis in mice.Semantic proximity Read ↗

Brca1 inactivation induces p27(Kip1)-dependent cell cycle arrest and delayed development in the mouse mammary gland.Semantic proximity Read ↗

Vitamin D inhibits the formation of prostatic intraepithelial neoplasia in Nkx3.1;Pten mutant mice.Semantic proximity Read ↗

Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis.Semantic proximity Read ↗

Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1.Semantic proximity Read ↗

Cyclin-dependent kinase inhibitor p27(Kip1) is required for mouse mammary gland morphogenesis and function.Semantic proximity Read ↗

Loss of the cyclin kinase inhibitor p27kip1 opens a therapeutic window by deregulating pathway choice after DNA double strand breaksSemantic proximity Read ↗

Prostatic intraepithelial neoplasia in mice with conditional disruption of the retinoid X receptor alpha allele in the prostate epithelium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.