Article

Loss of the cyclin kinase inhibitor p27kip1 opens a therapeutic window by deregulating pathway choice after DNA double strand breaks

2023-05-15

Abstract excerpt

<title>Abstract</title> <p>Reduced expression of the cyclin kinase inhibitor p27kip1 is found in many human tumors and correlates with inferior prognosis. We tested the importance of p27 loss for the induction of genetic instability in Notch driven cholangiocarcinoma (CCA). Specifically, we asked how loss of p27 interferes with DNA repair pathway choice i.e. non-homologous-end-joining (NHEJ) or homologous recombi...

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Literature Corpus work: a6d4e82a-8bab-54e6-8156-4e3b4a67119a
DOI: 10.21203/rs.3.rs-2889500/v1

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