Article
Pharmacogenomic diversity in Singaporean populations and Europeans.
The pharmacogenomics journal - 1 Dec 2014
Brunham L R, Chan S L, Li R, Aminkeng F, Liu X, Saw W Y, Ong R T H, Pillai E N, Carleton B C, Toh D, Tan S H, Koo S H, Lee E J D, Chia K S, Ross C J D, Hayden M R, Sung C, Teo Y Y
Abstract excerpt
Differences in the frequency of pharmacogenomic variants may influence inter-population variability in drug efficacy and risk of adverse drug reactions (ADRs). We investigated the diversity of ∼ 4500 genetic variants in key drug-biotransformation and -response genes among three South East Asian populations compared with individuals of European ancestry. We compared rates of reported ADRs in these Asian...
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