Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression.

doi:10.1186/1471-2466-10-51

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Article

Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression.

BMC pulmonary medicine - 7 Oct 2010

Bournazos Stylianos, Grinfeld Jacob, Alexander Karen M, Murchison John T, Wallace William A, McFarlane Pauline, Hirani Nikhil, Simpson A John, Dransfield Ian, Hart Simon P

Abstract excerpt

BACKGROUND: A significant genetic component has been described for idiopathic pulmonary fibrosis (IPF). The R131H (rs1801274) polymorphism of the IgG receptor FcγRIIa determines receptor affinity for IgG subclasses and is associated with several chronic inflammatory diseases. We investigated whether this polymorphism is associated with IPF susceptibility or progression. METHODS: In a case-control study, we...

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PMID: 20929558
DOI: 10.1186/1471-2466-10-51
PMCID: PMC2958991

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