Article
HMGA proteins regulate the expression of FGF2 in uterine fibroids.
Molecular human reproduction - 1 Feb 2011
Helmke Burkhard Maria, Markowski Dominique Nadine, Müller Marietta Henrike, Sommer Anette, Müller Jörg, Möller Carsten, Bullerdiek Jörn
Abstract excerpt
In human fibroids genes encoding the high-mobility proteins containing the 'AT-hook' DNA-binding motif (HMGA) are frequently affected by non-random chromosomal rearrangements. Thus, the different proteins and their derivatives resulting from these genomic rearrangements can be assumed to be involved in the genesis of these tumors by activation of largely identical downstream pathways. Constructs encoding HMGA...
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