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Article

Antiproliferative Effects by <i>Let-7</i> Repression of High-Mobility Group A2 in Uterine Leiomyoma

1 Apr 2008

Abstract excerpt

High-mobility group A2 (HMGA2) is commonly overexpressed in large leiomyomas. HMGA2 is an important regulator of cell growth, differentiation, apoptosis, and transformation. As a predicted target of Let-7 microRNAs (Let-7s), HMGA2 can be repressed by Let-7s in vitro. MicroRNA profiling analysis revealed that Let-7s were significantly dysregulated in uterine leiomyomas: high in small leiomyomas and lower in large...

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PMID: 18403645
DOI: 10.1158/1541-7786.mcr-07-0370

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