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Article

RAFFI: Accurate and fast familial relationship inference in large scale biobank studies using RaPID.

PLoS genetics - 1 Jan 2021

Naseri Ardalan, Shi Junjie, Lin Xihong, Zhang Shaojie, Zhi Degui

Abstract excerpt

Inference of relationships from whole-genome genetic data of a cohort is a crucial prerequisite for genome-wide association studies. Typically, relationships are inferred by computing the kinship coefficients (ϕ) and the genome-wide probability of zero IBD sharing (π0) among all pairs of individuals. Current leading methods are based on pairwise comparisons, which may not scale up to very large cohorts (e.g.,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33476339
DOI: 10.1371/journal.pgen.1009315
PMCID: PMC7853505

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