Article
Enrichment analyses identify shared associations for 25 quantitative traits in over 600,000 individuals from seven diverse ancestries.
American journal of human genetics - 5 May 2022
Smith Samuel Pattillo, Shahamatdar Sahar, Cheng Wei, Zhang Selena, Paik Joseph, Graff Misa, Haiman Christopher, Matise T C, North Kari E, Peters Ulrike, Kenny Eimear, Gignoux Chris, Wojcik Genevieve, Crawford Lorin, Ramachandran Sohini
Abstract excerpt
Since 2005, genome-wide association (GWA) datasets have been largely biased toward sampling European ancestry individuals, and recent studies have shown that GWA results estimated from self-identified European individuals are not transferable to non-European individuals because of various confounding challenges. Here, we demonstrate that enrichment analyses that aggregate SNP-level association statistics at...
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