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A comparison of ARMS and DNA sequencing for mutation analysis in clinical biopsy samples

6 Oct 2010

Abstract excerpt

BACKGROUND: We have compared mutation analysis by DNA sequencing and Amplification Refractory Mutation System™ (ARMS™) for their ability to detect mutations in clinical biopsy specimens. METHODS: We have evaluated five real-time ARMS assays: BRAF 1799T>A, [this includes V600E and V600K] and NRAS 182A>G [Q61R] and 181C>A [Q61K] in melanoma, EGFR 2573T>G [L858R], 2235-2249del15 [E746-A750del] in non-small-cell lung...

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PMID: 20925915
DOI: 10.1186/1756-9966-29-132

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