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Article

Gender-associated differences of perforin polymorphisms in the susceptibility to multiple sclerosis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2010

Camiña-Tato Montse, Morcillo-Suárez Carlos, Bustamante Marta F, Ortega Israel, Navarro Arcadi, Muntasell Aura, López-Botet Miguel, Sánchez Alex, Carmona Paco, Julià Eva, Tortola María Teresa, Audí Laura, Oksenberg Jorge R, Martin Roland, Montalban Xavier, Comabella Manuel

Abstract excerpt

The granule-dependent exocytosis pathway is an important mechanism to induce apoptosis by CD8(+) T cells and NK cells and involves lytic molecules such as perforin. In the current study, we investigated the perforin 1 gene (PRF1) as a candidate for multiple sclerosis (MS) susceptibility in the Spanish population. We genotyped three PRF1 single nucleotide polymorphisms (rs885822, rs10999426, and rs3758562) in 420...

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Share to CD8-Positive T-Lymphocytes
Share to Cell Separation
Share to Flow Cytometry
Share to Killer Cells, Natural
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Share to Pore Forming Cytotoxic Proteins
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Source

Identifiers

PMID: 20921521
DOI: 10.4049/jimmunol.1000102

Genes

PRF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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