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Article

Genetic association of CASP8 polymorphisms with primary progressive multiple sclerosis.

Journal of neuroimmunology - 1 May 2010

Camiña-Tato M, Fernández M, Morcillo-Suárez C, Navarro A, Julià E, Edo M C, Montalban X, Comabella M

Abstract excerpt

We investigated caspase 8 (CASP8) as a candidate gene for multiple sclerosis (MS) susceptibility. Three SNPs (rs2037815, rs12990906 and rs1035140) were genotyped in 546 MS patients and 547 controls. For SNP rs2037815, GG homozygosity was associated with primary progressive multiple sclerosis (PPMS) when compared with relapse-onset MS and controls. We identified risk (GCA) and protective (ACT) haplotypes...

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Topics

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Share to Genetic Testing
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Share to Disease Progression
Share to Homozygote
Share to Linkage Disequilibrium
Share to Multiple Sclerosis, Chronic Progressive
Share to Multiple Sclerosis, Relapsing-Remitting
Share to Severity of Illness Index

Source

Identifiers

PMID: 20363033
DOI: 10.1016/j.jneuroim.2010.03.003

Genes

CASP8
GCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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