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Nod1 and Nod2 Regulation of Inflammation in the <i>Salmonella</i> Colitis Model

5 Oct 2010

Abstract excerpt

The pattern recognition molecules Nod1 and Nod2 play important roles in intestinal homeostasis; however, how these proteins impact on the development of inflammation during bacterial colitis has not been examined. In the streptomycin-treated mouse model of Salmonella colitis, we found that mice deficient for both Nod1 and Nod2 had attenuated inflammatory pathology, reduced levels of inflammatory cytokines, and...

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PMID: 20921147
DOI: 10.1128/iai.00759-10

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