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Article

Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum

2 Aug 2010

Abstract excerpt

Mutations in the NOD2 gene are strong genetic risk factors for ileal Crohn's disease. However, the mechanism by which these mutations predispose to intestinal inflammation remains a subject of controversy. We report that Nod2-deficient mice inoculated with Helicobacter hepaticus, an opportunistic pathogenic bacterium, developed granulomatous inflammation of the ileum, characterized by an increased expression of...

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PMID: 20679225
DOI: 10.1073/pnas.1003363107

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