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Article

Interrogating local population structure for fine mapping in genome-wide association studies.

Bioinformatics (Oxford, England) - 1 Dec 2010

Qin Huaizhen, Morris Nathan, Kang Sun J, Li Mingyao, Tayo Bamidele, Lyon Helen, Hirschhorn Joel, Cooper Richard S, Zhu Xiaofeng

Abstract excerpt

MOTIVATION: Adjustment for population structure is necessary to avoid bias in genetic association studies of susceptibility variants for complex diseases. Population structure may differ from one genomic region to another due to the variability of individual ancestry associated with migration, random genetic drift or natural selection. Current association methods for correcting population stratification usually...

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PMID: 20889494
DOI: 10.1093/bioinformatics/btq560
PMCID: PMC2982153

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LCT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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