Article
Calibrating Population Stratification in Association Analysis.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017
Qin Huaizhen, Zhu Xiaofeng
Abstract excerpt
In genetic association studies, it is necessary to correct for population structure to avoid inference bias. During the past decade, prevailing corrections often only involved adjustments of global ancestry differences between sampled individuals. Nevertheless, population structure may vary across local genomic regions due to the variability of local ancestries associated with natural selection, migration, or...
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