Article
Role of ADP-ribosylation factor 6 (ARF6) in gastric acid secretion.
The Journal of biological chemistry - 19 Sept 2003
Matsukawa Jun, Nakayama Kazuhisa, Nagao Taku, Ichijo Hidenori, Urushidani Tetsuro
Abstract excerpt
ADP-ribosylation factor (ARF) proteins are monomeric GTPases that are essential for membrane transport and exocytosis in a number of secretory cells. We investigated ARF6, the activation of which is insensitive to brefeldin A, to determine whether it regulates membrane traffic in gastric parietal cells. ARF6 translocated from cytosol to tubulovesicle in the presence of GTPgammaS, a potential inhibitor of acid...
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