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Article

Role of the Osteoblast Lineage in the Bone Marrow Hematopoietic Niches

3 Mar 2009

Abstract excerpt

In mammals, hematopoiesis shifts to the bone marrow in late embryogenesis, coincident with the appearance of a marrow cavity.(1) There hematopoiesis is sustained throughout adult life unless forced out of the bone marrow into extramedullary sites by pathological conditions. All hematopoietic lineages arise from the hematopoietic stem cell (HSC), and maintenance of HSC self‐renewal and differentiation are...

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PMID: 19257832
DOI: 10.1359/jbmr.090225

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