Article
In vitro-expanded CD4(+)CD25(high)Foxp3(+) regulatory T cells controls corneal allograft rejection.
Human immunology - 1 Nov 2012
Guo Xuming, Jie Ying, Ren Dong, Zeng Hui, Zhang Yingnan, He Yan, Pan Zhiqiang
Abstract excerpt
AIMS: Natural CD4(+)CD25(+) regulatory cells (nTregs) have been implicated in maintaining peripheral immune tolerance. This study aims to test whether immunotherapy using in vitro-expanded Treg (iTregs) could suppress allograft rejection in corneal transplantation model. METHODS: Natural CD4(+)CD25(+) T cells were freshly purified from naïve mice and expanded in vitro by culturing with anti-CD3/CD28-coated...
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