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Article

Experimental generation of SNP haplotype signatures in patients with sickle cell anaemia.

PloS one - 24 Sept 2010

Menzel Stephan, Qin Jian, Vasavda Nisha, Thein Swee Lay, Ramakrishnan Ramesh

Abstract excerpt

BACKGROUND: Sickle cell anemia is caused by a single type of mutation, a homozygous A→T substitution in the ß globin gene. Clinical severity is diverse, partially due to additional, disease-modifying genetic factors. We are studying one such modifier locus, HMIP (HBS1L-MYB intergenic polymorphism, chromosome 6q23.3). Working with a genetically admixed patient population, we have encountered the necessity to...

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Topics

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Share to Anemia, Sickle Cell
Share to Chromosomes, Human, Pair 6
Share to MYB gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Haplotypes

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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 20886046
DOI: 10.1371/journal.pone.0013004
PMCID: PMC2945316

Genes

MYB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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