Article
An accurate haplotyping method using multiplex pyrosequencing with AS-PCR to detect ABCB1 haplotypes associated with rivaroxaban-derived hemorrhagic events.
Talanta - 1 Jan 2025
Wang Shanshan, Wang Liteng, Wei Meng, Wang Lingfei, Yang Ziyun, Chen Chen, Ma Xueping, Chu Yana, Wu Haiping, Zhou Guohua
Abstract excerpt
In clinical practice, owing to the comprehensive genetic insights they offer, haplotypes have attracted greater attention than individual single nucleotide polymorphisms (SNPs). Due to the long distances across SNP locations, detecting the haplotype using genomic DNA is challenging. Current haplotyping methods are either expensive and labor-intensive (high-throughput DNA sequencing), or haplotyping a single...
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