Article
A common variant in the telomerase RNA component is associated with short telomere length.
PloS one - 27 Sept 2010
Njajou Omer T, Blackburn Elizabeth H, Pawlikowska Ludmila, Mangino Massimo, Damcott Coleen M, Kwok Pui-Yan, Spector Timothy D, Newman Anne B, Harris Tamara B, Cummings Steven R, Cawthon Richard M, Shuldiner Alan R, Valdes Ana M, Hsueh Wen-Chi
Abstract excerpt
BACKGROUND: Telomeres shorten as cells divide. This shortening is compensated by the enzyme telomerase. We evaluated the effect of common variants in the telomerase RNA component (TERC) gene on telomere length (TL) in the population-based Health Aging and Body Composition (Health ABC) Study and in two replication samples (the TwinsUK Study and the Amish Family Osteoporosis Study, AFOS). METHODOLOGY: Five variants...
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