Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis.

doi:10.1111/j.1474-9726.2011.00775.x

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Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis.

Aging cell - 1 Apr 2012

Soerensen Mette, Thinggaard Mikael, Nygaard Marianne, Dato Serena, Tan Qihua, Hjelmborg Jacob, Andersen-Ranberg Karen, Stevnsner Tinna, Bohr Vilhelm A, Kimura Masayuki, Aviv Abraham, Christensen Kaare, Christiansen Lene

Abstract excerpt

Telomerase is of key importance for telomere maintenance, and variants of the genes encoding its major subunits, telomerase reverse transcriptase (TERT) and telomerase RNA component (TERC), are candidates for interindividual variation in telomere length. Recently, the two SNPs rs3772190 and rs12696304 in the TERC locus were reported to be associated with leukocyte telomere length (LTL) in two genome-wide...

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PMID: 22136229
DOI: 10.1111/j.1474-9726.2011.00775.x
PMCID: PMC3303949

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TERT

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Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis.PMID 22136229Read ↗

A genome-wide association study identifies a locus on TERT for mean telomere length in Han Chinese.Semantic proximity Read ↗

Common variants near TERC are associated with leukocyte telomere length in the Chinese Han population.Semantic proximity Read ↗

Common variants near TERC are associated with mean telomere length.Semantic proximity Read ↗

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Common variants of human TERT and TERC genes and susceptibility to sporadic Alzheimers disease.Semantic proximity Read ↗

The functional VNTR MNS16A of the TERT gene is associated with human longevity in a population of Central Italy.Semantic proximity Read ↗

TERC Variants Associated with Short Leukocyte Telomeres: Implication of Higher Early Life Leukocyte Telomere Attrition as Assessed by the Blood-and-Muscle Model.Semantic proximity Read ↗

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