Article
Genetic susceptibility to telomere shortening through the rs2293607 polymorphism is associated with a greater risk of alcohol use disorder.
Mechanisms of ageing and development - 1 Sept 2022
Llorente Hernán, Perez-Rivera Jose-Angel, Perez-Nieto María, Cieza-Borrella Clara, Pastor Isabel, Novo-Veleiro Ignacio, Fernández-Mateos Javier, Chamorro Antonio-Javier, Crecente-Otero Patricia, Laso Francisco-Javier, González-Sarmiento Rogelio, Marcos Miguel
Abstract excerpt
Telomere shortening is usually considered a biomarker of ageing. Harmful alcohol use promotes accelerated biological ageing and alcohol use disorders (AUDs) are associated with short telomere length (TL). This study was conducted to examine the relationship of TL to AUD and determine whether single nucleotide polymorphisms (SNPs) in TERC and TERT modulate this association. For this purpose, we genotyped TERC SNPs...
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