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Article

CMV promoter is inadequate for expression of mutant human RyR2 in transgenic rabbits.

Journal of pharmacological and toxicological methods - 1 Jan 2000

Wakula Paulina, Bisping Egbert, Kockskämper Jens, Post Heiner, Brauer Sabine, Deuter Marion, Oehlmann Ralph, Besenfelder Urban, Lai F Anthony, Brem Gottfried, Pieske Burkert

Abstract excerpt

INTRODUCTION: Fundamental differences in Ca²+ homeostasis between mice and larger mammals require the validation of the mechanisms of arrhythmogenesis before translation into human pathophysiology. The purpose of this study was to create transgenic rabbits that express defective human cardiac ryanodine receptor (hRyR2) with a mutation (R4497C) causing a clinically relevant arrhythmogenic syndrome. METHODS: The...

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Identifiers

PMID: 20883803
DOI: 10.1016/j.vascn.2010.09.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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