In vivo short-term expression of a hypertrophic cardiomyopathy mutation in adult rabbit myocardium: myofibrillar incorporation without early disarray.

doi:10.1046/j.1525-1381.1999.09416.x

Back to search

Article

In vivo short-term expression of a hypertrophic cardiomyopathy mutation in adult rabbit myocardium: myofibrillar incorporation without early disarray.

Proceedings of the Association of American Physicians - 1 Jan 2000

Yu Q, Zhao G, Marian A J

Abstract excerpt

Cardiac myocyte disarray is the pathological hallmark of hypertrophic cardiomyopathy (HCM), a disease of sarcomeric proteins. Mutations in the cardiac troponin T (cTnT), a major gene responsible for HCM, are associated with severe myocyte disarray. To study the pathogenesis of cardiac myocyte dis...

Topics

Adenoviridae
Animals
Cardiomyopathy, Hypertrophic
Disease Models, Animal
Genetic Vectors
Humans
Mutation
Myocardium
Myofibrils
Rabbits
Transfection
Troponin T

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.