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Article

Molecular basis of species-specific expression of repolarizing K+currents in the heart

1 Oct 2003

Abstract excerpt

There are important species-specific differences in K+ current profiles and arrhythmia susceptibility, but interspecies comparisons of K+ channel subunit expression are lacking. We quantified voltage-gated K+ channel (Kv) subunit mRNA and protein in rabbits, guinea pigs, and humans. Kv1.4, Kv4.2, and Kv4.3 mRNA was present in rabbits but undetectable in guinea pigs. MinK mRNA concentration in guinea pigs was...

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PMID: 12816752
DOI: 10.1152/ajpheart.00346.2003

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