Article
Cardiac phenotype induced by a dysfunctional α 1C transgene: a general problem for the transgenic approach.
Channels (Austin, Tex.) - 1 Jan 2000
Asemu Girma, Fishbein Kenneth, Lao Qi Zong, Ravindran Arippa, Herbert Ron, Canuto Holly C, Spencer Richard G, Soldatov Nikolai M
Abstract excerpt
Based on stable integration of recombinant DNA into a host genome, transgenic technology has become an important genetic engineering methodology. An organism whose genetic characteristics have been altered by the insertion of foreign DNA is supposed to exhibit a new phenotype associated with the function of the transgene. However, successful insertion may not be sufficient to achieve specific modification of...
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