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Article

Genetically modified rabbit models for cardiovascular medicine.

European journal of pharmacology - 5 May 2022

Hou Ying, Zhang Xin, Sun Xia, Qin Qiaohong, Chen Di, Jia Min, Chen Yulong

Abstract excerpt

Genetically modified (GM) rabbits are outstanding animal models for studying human genetic and acquired diseases. As such, GM rabbits that express human genes have been extensively used as models of cardiovascular disease. Rabbits are genetically modified via prokaryotic microinjection. Through this process, genes are randomly integrated into the rabbit genome. Moreover, gene targeting in embryonic stem (ES)...

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PMID: 35300995
DOI: 10.1016/j.ejphar.2022.174890

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